Xanax tolerance develops at different rates.
Xanax tolerance develops within 8 weeks to the anti-anxiety, panic and sedative effects. Studies indicate that Xanax has little effect on the original base-line symptoms after 8 weeks of use. In fact, Xanax can aggravate original symptoms and can cause dependence in less than a month. Xanax is a short-acting benzodiazepine, which means that the effects of the drug are short lived because Xanax does not stay long in the body. The combination of Xanax tolerance and short-acting nature of the drug, causes the user to increase dosage to maintain effects. Approximately three million Americans (1.6% of the adult population) have used benzodiazepines on a daily basis for at least 12 months or much longer
Tolerance develops and adverse effects increase
Xanax causes the most tolerance, dependence and withdrawal complications of all of the benzodiazepines. The short-acting effects of the drug gives the long-term and high dose user between dose withdrawal. The combination of which makes Xanax the most potentially addictive benzodiazepine and has the most people addicted to it. It is after all the most sold benzodiazepine in America which attests to its addiction potential.
As the dosage and length of use increase the brain and body must make adjustments to maintain it’s natural equilibrium. If this continues long enough the level of xanax gets so high in the body that it nears or reaches a persons toxicity for that particular drug. When this happens physical dependence occurs and the user will have Xanax withdrawal. Numerous studies have revealed that tolerance develops to the panic and anxiolytic (anti-anxiety) effects within a couple of months. Users taking Xanax for the anti-anxiety need to increase dosage for the drug to keep working. In a study over 25% of the patients were taking two benzodiazepines, an extra benzo been added to the prescription when the first one stopped working.
There are several studies that indicate that one third of the people will develop Xanax dependence with regular, therapeutic use. Xanax dependence brings much more exaggerated symptoms of panic, anxiety and insomnia when users withdrawal and at times between doses. The implications of these two facts in combination strongly suggests that regular prescribed therapy of longer than two months has created large populations of unintentional addicts at the advice of their own doctor.
Chronic use of Xanax leads to Xanax tolerance with a decrease in the effectiveness of benzodiazepine binding sites. The longer Xanax is taken the more ineffective the bodies GABA receptors are. When dosage is increased to adjust for tolerance the pathology of the brain adjusts by reducing the usable receptors. This leads to increasing psychological and physical symptoms. Chronic use of Xanax cause many other adverse effects including depression, excessive sleepiness, road traffic and other accidents (especially with alcohol). Xanax is not soluble in water, when crushed in water it will not full dissolve. Xanax injection have been reported, causing dangerous damage to blood vessels, closure of blood vessels and decay of muscle tissue. There have also been reports of xanax being snorted.